Acetic Acid → 3,4-Dimethyl-2-nitrophenol

HRID 565006Notes

Reaction equation

HRID 565006 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[CH3:8].C(O)(=O)C.[N+:14]([O-])([OH:16])=[O:15]>O>[CH3:1][C:2]1[C:3]([N+:14]([O-:16])=[O:15])=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[CH3:8]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 944Nitric AcidHCID 72493,4-Dimethylphenol

Product 1

HCID 135714543,4-Dimethyl-2-nitrophenol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The reaction was carried out in a manner similar to Reference Example 20 a) except for using 15.7 g (129 mmol) of 3,4-dimethylphenol, 130 ml of acetic acid, 8 ml of water and 12.2 g (135 mmol) of 70% nitric acid. 3,4-Dimethyl-2-nitrophenol was thus obtained in the yield of 7.01 g (26.0%).

Sources & evidence

ORD record
ord-745752e23dbf440584513d8a3a3b1f84
Source dataset
uspto-grants-2001_01
Patent number
US06169107A

Reaction notes

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