Hydrochloride methanol → HCID 178485139, compound

HRID 565055Notes

Reaction equation

[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N+:18]([O-:20])=[O:19])=[C:7]2[C:3]=1[CH:4]=[C:5]([C:21]([N:23]=[C:24]([NH2:27])[NH:25][CH3:26])=[O:22])[NH:6]2.Cl.CO>>[ClH:1].[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N+:18]([O-:20])=[O:19])=[C:7]2[C:3]=1[CH:4]=[C:5]([C:21]([N:23]=[C:24]([NH2:27])[NH:25][CH3:26])=[O:22])[NH:6]2

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 178485138HCID 178485138, compound

Product 1

HCID 178485139HCID 178485139, compound

Procedure

4-Chloro-1-methyl-7-(2-nitrophenoxy)-2-indoloylguanidine obtained as the intermediate in Example 188 was converted into the hydrochloride with hydrogen chloride/methanol to give 4-chloro-1-methyl-7-(2-nitrophenoxy)-2-indoloylguanidine hydrochloride.

Sources & evidence

ORD record: ord-f4823e74b7c64bd0a0d3eaaae0c10edb
Source dataset: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06169107A

Reaction notes

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