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HRID5651

反应详情

EQUATION

反应方程式

HRID 5651 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)OC(C)=O
HCID7918

Acetic anhydride

C4H6O3

结构：CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(N)c1
HCID15270288

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(NC(C)=O)c1
HCID15270290

3-Ethyl 5-methyl 4-[3-(acetylamino)phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

C20H24N2O5

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

Under inert gas atmosphere Ac2O (43 mcl) is added to a stirred solution of (-)-2,6-dimethyl-3-carboethoxy-5-carbomethoxy-4-(3-aminophenyl)-1,4-dihydropyridine (100 mg) in pyridine (ml 1). 90 minutes after dilution with water (ml 50), extraction with AcOEt (3×10 ml) and crystallization from Et2O 70/EtOH 10, give mg 85 of +)-2,6-dimethyl-3-carboethoxy-5-carbomethoxy-4-(3-acetylaminophenyl)-1,4-dihydropyridine m.p. 197°-199° C. [α]D =+0.87°, [α]578 =+2.00°, [α]546 =+1.64° c=2.2 DMF.

WORKUP

后处理

  1. extraction90 minutes after dilution with water (ml 50), extraction
  2. customwith AcOEt (3×10 ml) and crystallization from Et2O 70/EtOH 10