反应详情

To a mixture of 5,5-dimethyl-3-hydroxy-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (500 mg, 1.77 mmol, Example 109, Step 1) in DMF (6 mL) were added NaH (65 mg, 1.2 eq.), and neopentyl iodide (585 μL). After a period of 18 h at 70° C., the reaction mixture was diluted with EtOAc. The mixture was washed with H2O and the organic phase separated, dried over MgSO4 and evaporated under reduced pressure. The resulting oil was purified by flash chromatography to provide the title compound (124 mg) as a white solid after precipitation with Et2O.

1. washThe mixture was washed with H2O
2. customthe organic phase separated
3. dry with materialdried over MgSO4
4. customevaporated under reduced pressure
5. customThe resulting oil was purified by flash chromatography