反应详情

温度

130 °C

To the mixture of 3-diazo-2,4-(3H, 5H)-furandione (300 mg, 2.38 mmol; Example 207, Step 1) and α-methylcyclopropanemethanol (2.0 mL) was added rhodium acetate (30 mg). The mixture was heated at 130° C. for a period of 18 h. The excess of alcohol was evaporated under reduced pressure and the resulting crude mixture was purified by flash chromatography (10% to 20% MeOH in CH2Cl2 ) to provide 50 mg of the title compound.

1. customThe excess of alcohol was evaporated under reduced pressure
2. customthe resulting crude mixture was purified by flash chromatography (10% to 20% MeOH in CH2Cl2 )