反应详情

A mixture of 2,3-dihydroxybenzoic acid(994 g), ethanol (3.8 L) and sulfuric acid (320 g) was refluxed for 44 hours. A portion of the solvent distilled out of the solution, and the solution was cooled and stirred overnight, and then further cooled in an ice/water bath. To the solution was added water (5.6 L). The solution was aged, and the crystals were filtered, washed with water, and dried to give ethyl 2,3-dihydroxybenzoate (1002 g, 85%); m.p. 66.0-67.2° C.

1. temperaturewas refluxed for 44 hours
2. distillationA portion of the solvent distilled out of the solution
3. temperaturethe solution was cooled
4. temperaturefurther cooled in an ice/water bath
5. additionTo the solution was added water (5.6 L)
6. filtrationthe crystals were filtered
7. washwashed with water
8. customdried