Trifluoroacetic acid → HCID 61148470, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (2S)-2-tert-butoxycarbonylamino-3,3-dimethylbutanoic acid 2-pyridylmethylamide (16 g, 50 mmol) in dichloromethane (25 mL) cooled at 0° C. is added trifluoroacetic acid (150 mL). The resulting solution is allowed to warm to 25° C. and is stirred for 18 h. The reaction mixture is diluted with toluene, concentrated, brought to pH=10 with 2 M sodium hydroxide, and extracted with 3:1 dichloromethane/isopropanol (200 mL). The organic layer is washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to provide (2S)-2-Amino-3,3-dimethylbutanoic acid 2-pyridylmethylamide (11 g, 100% yield) as a white solid.

Provenance & Evidence