HCID 12052034, compound → HCID 12052035, compound

HRID 565281Notes

Reaction equation

HRID 565281 reaction equation
C([O:3][C:4](=[O:18])[CH:5]([S:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)[CH:6]([CH3:8])[CH3:7])C>CO.[OH-].[Na+]>[CH3:17][O:16][C:13]1[CH:12]=[CH:11][C:10]([S:9][CH:5]([CH:6]([CH3:8])[CH3:7])[C:4]([OH:18])=[O:3])=[CH:15][CH:14]=1

Participants

4

Reactant 1

HCID 12052034HCID 12052034, compound

Product 1

HCID 12052035HCID 12052035, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

2-(4-Methoxy-phenylsulfanyl)-3-methyl-butyric acid was prepared starting from 2-(4-methoxy-phenylsulfanyl)-3-methyl-butyric acid ethyl ester (5.8 g, 21.6 mmol) dissolved in methanol (50 ml) and 10 N NaOH (30 ml). The resulting reaction mixture was worked up as outlined in Example 1. Yield 5.0 g, 99%. Low melting solid. MS: 242 (M+H)+.

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-12645f3ad51d41abb69fd691a1c6f1a4
Source dataset
uspto-grants-2001_01
Patent number
US06172057B2

Reaction notes

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