HCID 53756990, compound → HCID 18416721, compound

HRID 565292Notes

Reaction equation

HRID 565292 reaction equation
C([O:3][C:4](=[O:36])[C:5]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][CH2:29][CH2:30][N:31]([CH2:34][CH3:35])[CH2:32][CH3:33])=[CH:24][CH:23]=1)([S:10]([C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1)(=[O:12])=[O:11])[CH2:6][CH2:7][CH2:8][CH3:9])C>CO.[OH-].[Na+]>[CH2:34]([N:31]([CH2:32][CH3:33])[CH2:30][CH2:29][O:28][C:25]1[CH:24]=[CH:23][C:22]([CH2:21][C:5]([S:10]([C:13]2[CH:14]=[CH:15][C:16]([O:19][CH3:20])=[CH:17][CH:18]=2)(=[O:11])=[O:12])([CH2:6][CH2:7][CH2:8][CH3:9])[C:4]([OH:36])=[O:3])=[CH:27][CH:26]=1)[CH3:35]

Participants

4

Reactant 1

HCID 53756990HCID 53756990, compound

Product 1

HCID 18416721HCID 18416721, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

2-[4-(2-Diethylamino-ethoxy)-benzyl]-2-(4-methoxy-benzenesulfonyl)-hexanoic acid was prepared starting from 2-[4-(2-diethylamino-ethoxy)-benzyl]-2-(4-methoxy-benzenesulfonyl)-hexanoic acid ethyl ester (8 g, 15.4 mmol) dissolved in methanol (200 ml) and 10 N NaOH (30 ml). The resulting mixture was worked up as outlined in example 1. Yield 3.88 g crude (51%); brown oil; MS: 492 (M+H)+.

Sources & evidence

ORD record
ord-f29a556ee6b14e0cb9dcb292ad434e36
Source dataset
uspto-grants-2001_01
Patent number
US06172057B2

Reaction notes

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