huagongshe.com
HRID56530

反应详情

EQUATION

反应方程式

HRID 56530 的结构方程式

REACTANTS

反应物

2
结构：COc1cc(-c2ccco2)cc(OC)c1Br
HCID58431988

未命名化合物

结构：COC(C(=O)N(C)OC)c1cccc2ncccc12
HCID58432006

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(-c2ccc(C(=O)C(OC)c3cccc4ncccc34)o2)cc(OC)c1Br
HCID58432132

未命名化合物

收率 46%

PROCEDURE

实验过程

1-(5-(4-Bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(quinolin-5-yl)ethanone was synthesized from N,2-dimethoxy-N-methyl-2-(quinolin-5-yl)acetamide and 2-(4-bromo-3,5-dimethoxyphenyl)furan following the procedure used for the synthesis of Example 12. Purification by chromatography (EtOAc-hexanes) provided 1-(5-(4-bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(quinolin-5-yl)ethanone as a light yellow foam (0.102 g, 46% yield). MS: m/z 482.1 [M+H]+.

WORKUP

后处理

  1. customused for the synthesis of Example 12
  2. customPurification by chromatography (EtOAc-hexanes)