2-Methyl-2-(2-methyl-furan-3-sulfonyl)-3-[4-(2-piperidin-yl-ethoxy)-phenyl]-propionic acid ethyl ester → 2-Methyl-2-(2-methyl-furan-3-sulfonyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-propionic acid
Reaction equation
C([O:3][C:4](=[O:32])[C:5]([CH3:31])([S:22]([C:25]1[CH:29]=[CH:28][O:27][C:26]=1[CH3:30])(=[O:24])=[O:23])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[CH:9][CH:8]=1)C>C(O)C.[OH-].[Na+]>[CH3:31][C:5]([S:22]([C:25]1[CH:29]=[CH:28][O:27][C:26]=1[CH3:30])(=[O:24])=[O:23])([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][N:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)=[CH:9][CH:8]=1)[C:4]([OH:32])=[O:3]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
2-Methyl-2-(2-methyl-furan-3-sulfonyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-propionic acid was prepared according to the general method as outlined in example 1. Starting from 2-methyl-2-(2-methyl-furan-3-sulfonyl)-3-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-propionic acid ethyl ester (2.01 g, 4.5 mmol), dissolved in ethanol (20 mL) and 10 N sodium hydroxide (10 mL). The resulting mixture was worked up as outline in example 9. Yield 2.03g; amber crystals mp 66-68° C.; MS 434 (M−H).
Sources & evidence
- ORD record
- ord-4633c2159b4142f39c1879a59f113c97
- Source dataset
- uspto-grants-2001_01
- Patent number
- US06172057B2
Reaction notes
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