4-(2-Piperidin-1-yl-ethoxy)benzyl chloride → 2-(Octane-1-sulfonyl) 3-[4-(2-piperidin-yl-ethoxy)phenyl]-propionic acid ethyl ester

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Reaction Steps

2-(Octane-1-sulfonyl)-3-[4-(2-piperidin-yl-ethoxy)-phenyl]-propionic acid ethyl ester was prepared according to the general method as outlined in example 9. Starting from 2-(octane-1-sulfonyl)-propionic acid ethyl ester (5.0g, 18 mmol) and 1-[2-(4-chloromethylphenoxy)-ethyl]-piperidine (5.6g, 19.7 mmol); Yield 8.9g (96%); amber oil, MS 495.

Provenance & Evidence