Sodium Hydroxide → 2-(Octane-1-sulfonyl)3-[4-(2-piperidin-yl-ethoxy)phenyl]-propionic acid

HRID 565303Notes

Reaction equation

HRID 565303 reaction equation
C([O:3][C:4](=[O:33])[CH:5]([S:22]([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])(=[O:24])=[O:23])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[CH:9][CH:8]=1)C.[OH-].[Na+]>C(O)C>[CH2:25]([S:22]([CH:5]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][N:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)=[CH:9][CH:8]=1)[C:4]([OH:33])=[O:3])(=[O:24])=[O:23])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 109618722-(Octane-1-sulfonyl) 3-[4-(2-piperidin-yl-ethoxy)phenyl]-propionic acid ethyl ester

Product 1

HCID 212679752-(Octane-1-sulfonyl)3-[4-(2-piperidin-yl-ethoxy)phenyl]-propionic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(Octane-1-sulfonyl)-3-[4-(2-piperidin-yl-ethoxy)-phenyl]-propionic acid was prepared according to the general method as outlined in example 9. Starting from 2-(octane-1-sulfonyl)-3-[4-(2-piperidin-yl-ethoxy)-phenyl]-propionic acid ethyl ester (8.9g, 18 mmol), ethanol (25 mL) and 10 N sodium hydroxide (25 mL). Yield 6.0g (72%).

Sources & evidence

ORD record
ord-1a443880b33a4cf5a0f9422c9c206068
Source dataset
uspto-grants-2001_01
Patent number
US06172057B2

Reaction notes

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