Sodium Hydroxide → 3-Biphenyl-4-yl-2-methyl-2-(1-methyl-1H-imidazole-2-sulfonyl)-propionic acid

HRID 565305Notes

Reaction equation

HRID 565305 reaction equation
C([O:3][C:4](=[O:29])[C:5]([CH3:28])([S:19]([C:22]1[N:23]([CH3:27])[CH:24]=[CH:25][N:26]=1)(=[O:21])=[O:20])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:9][CH:8]=1)C.[OH-].[Na+]>C(O)C>[C:10]1([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:9]=[CH:8][C:7]([CH2:6][C:5]([CH3:28])([S:19]([C:22]2[N:23]([CH3:27])[CH:24]=[CH:25][N:26]=2)(=[O:21])=[O:20])[C:4]([OH:29])=[O:3])=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 542273063-Biphenyl-4-yl-2-methyl-2-(1-methyl-1H-imidazole-2-sulfonyl)propionic acid ethyl ester

Product 1

HCID 184169423-Biphenyl-4-yl-2-methyl-2-(1-methyl-1H-imidazole-2-sulfonyl)-propionic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-Biphenyl-4-yl-2-methyl-2-(1-methyl-1H-imidazole-2-sulfonyl)-propionic acid was prepared according to the general method as outlined in example 9. Starting from 3-biphenyl-4-yl-2-methyl2-(1-methyl-1H-imidazole-2-sulfonyl)-propionic acid ethyl ester (5.0 g, 11.9 mmol), ethanol (15 mL) and 10 N sodium hydroxide (10 mL). Yield 2.8 g (61%); brown solid mp 119-122° C.; MS 385.2 (M+H).

Sources & evidence

ORD record
ord-70a5076b86f74062951a5f7c7cb12b81
Source dataset
uspto-grants-2001_01
Patent number
US06172057B2

Reaction notes

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