Sodium Hydroxide → HCID 18416813, compound

HRID 565309Notes

Reaction equation

HRID 565309 reaction equation
C([O:3][C:4](=[O:33])[C:5]([S:23]([C:26]1[CH:31]=[CH:30][C:29]([Br:32])=[CH:28][CH:27]=1)(=[O:25])=[O:24])([CH3:22])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[CH:9][CH:8]=1)C.[OH-].[Na+]>C(O)C>[Br:32][C:29]1[CH:28]=[CH:27][C:26]([S:23]([C:5]([CH3:22])([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][N:16]3[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]3)=[CH:9][CH:8]=2)[C:4]([OH:33])=[O:3])(=[O:24])=[O:25])=[CH:31][CH:30]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 570331082-(4-Bromo-benzenesulfonyl)-2-methyl-3-[4-(2-piperidine-1-yl-ethoxy)-phenyl]-propionic acid ethyl ester

Product 1

HCID 18416813HCID 18416813, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(4-Bromo-benzenesulfonyl)-2-methyl-3-[4-(2-piperidine-1-yl-ethoxy)-phenyl]-propionic acid was prepared according to general method as outlined in example 9. Starting from 2-(4-bromo-benzenesulfonyl)-2-methyl-3-[4-(2-piperidine-1-yl-ethoxy)-phenyl]-propionic acid ethyl ester (6.5 g, 20 mmol), ethanol (30 mL) and 10 N sodium hydroxide (15 mL). Yield 6.3 g (100%); yellow solid mp 125-127° C.; MS 512.5 (M+H)+.

Sources & evidence

ORD record
ord-8c707fdd3bd64e3c8b5f7640d04b6f30
Source dataset
uspto-grants-2001_01
Patent number
US06172057B2

Reaction notes

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