HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 10873774, compound → HCID 11101592, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 10873774 | HCID 10873774 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | HCID 11101592 | HCID 11101592 | — |
Reaction Steps
1-(4-Fluoro-benzyl)-4-(4-methoxy-benzenesulfonyl)-piperidine-4-carboxylic acid was prepared starting from 1-(4-fluoro-benzyl)-4-(4-methoxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester (17.4 g, 40 mmol) dissolved in THF:methanol 3:1 and 10 N NaOH (40 ml). The resulting reaction mixture was worked up as outlined in example 83. Yield 10.8 g (66%); colorlesssolid; mp 154° C.; MS: 408 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06172057B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-34cf9166d2464596ae508d98555dfbee |
| Source note | uspto-grants-2001_01 |