HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Bromo-3,5-dimethoxyphenyl)furan → 1-(5-(4-Bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-(4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)phenyl)-2-methoxyethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Bromo-3,5-dimethoxyphenyl)furan | HCID 58431988 | — |
| Reactant | 2-(4-(5-Cyclopropyl-1,3,4-oxadiazol-2-yl)phenyl)-N,2-dimethoxy-N-methylacetamide | HCID 58432020 | — |
| Product | 1-(5-(4-Bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-(4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)phenyl)-2-methoxyethanone | HCID 58432060 | 31% |
Reaction Steps
2-(4-(5-Cyclopropyl-1,3,4-oxadiazol-2-yl)phenyl)-N,2-dimethoxy-N-methylacetamide was reacted with 2-(4-bromo-3,5-dimethoxyphenyl)furan according to the procedure for the synthesis of Example 12. Purification by chromatography (EtOAc-hexanes) gave 1-(5-(4-bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-(4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)phenyl)-2-methoxyethanone as a yellow foam (0.126 g, 31% yield). MS: m/z 539.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434707B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-d1b4e1d807024c7aa9db382690d91548 |
| Source note | uspto-grants-2016_09 |