Diethyl Ether → HCID 18002535, compound

HRID 565386Notes

Reaction equation

HRID 565386 reaction equation
[CH:1]1([N:13]2[CH2:28][CH2:27][C:16]3([N:20]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH2:19][CH2:18][CH2:17]3)[CH2:15][CH2:14]2)[C:11]2=[C:12]3[C:7](=[CH:8][CH:9]=[CH:10]2)[CH:6]=[CH:5][CH:4]=[C:3]3[CH2:2]1.C(OCC)C.CO.[ClH:36]>>[ClH:36].[CH:1]1([N:13]2[CH2:28][CH2:27][C:16]3([N:20]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH2:19][CH2:18][CH2:17]3)[CH2:15][CH2:14]2)[C:11]2=[C:12]3[C:7](=[CH:8][CH:9]=[CH:10]2)[CH:6]=[CH:5][CH:4]=[C:3]3[CH2:2]1

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 18002536HCID 18002536, compoundHCID 21893726Hydrochloride methanol

Product 1

HCID 18002535HCID 18002535, compoundYield 91%

Procedure

A stirred solution of (RS)-8-acenaphthen-1-yl-1-phenyl-1,8-diaza-spiro[4.5]decane (50 mg/see example 16) in 3N MeOH-HCl (0.2 ml) was treated with diethyl ether (5 ml). After 1 h the solid was filtered off to yield the desired product (50 mg, 91%) as a pale brown solid, m.p. 195° C. and MS: m/e=369.4 (M+H+).

Workup

  1. filtrationAfter 1 h the solid was filtered off

Sources & evidence

ORD record
ord-c36b59f33e9b465cb3e67e4069a3e5e3
Source dataset
uspto-grants-2001_01
Patent number
US06172075B2

Reaction notes

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