Fumaric Acid → HCID 86589625, compound

HRID 565388Notes

Reaction equation

HRID 565388 reaction equation
[CH2:1]1[CH:9]2[CH:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)[CH2:3][CH:2]1[N:10]1[CH2:26][CH2:25][C:13]2([N:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:16][CH2:15][CH:14]2[OH:24])[CH2:12][CH2:11]1.[C:27]([O-:34])(=[O:33])/[CH:28]=[CH:29]/[C:30]([O-:32])=[O:31].C(O)(=O)/C=C/C(O)=O>C(OCC)C>[C:27]([OH:34])(=[O:33])/[CH:28]=[CH:29]/[C:30]([OH:32])=[O:31].[CH2:1]1[CH:9]2[CH:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)[CH2:3][CH:2]1[N:10]1[CH2:26][CH2:25][C:13]2([N:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:16][CH2:15][C:14]2=[O:24])[CH2:12][CH2:11]1

Participants

5

Reactant 3

HCID 444972Fumaric AcidHCID 5460307FumarateHCID 18002526HCID 18002526, compound

Product 1

HCID 86589625HCID 86589625, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Oxidation of 8-(octahydro-inden-2-yl)-1-phenyl-1,8-diaza-spiro[4.5]decan-4-ol (mixture of diastereoisomers) according to the general method of example 20 and formation of the fumarate with fumaric acid in diethyl ether yielded the title compound, pale brown solid, m.p. 225° C. and MS: m/e=353.4 (M+H+).

Sources & evidence

ORD record
ord-96f7b6a7f3094b3ab79e3c4f4978b1c7
Source dataset
uspto-grants-2001_01
Patent number
US06172075B2

Reaction notes

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