HRID56540

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID58431993

未命名化合物

结构：COc1cc(-c2ccco2)cc(OC)c1OC(=O)c1ccccc1

HCID58431996

未命名化合物

PRODUCTS

生成物

结构：COc1cc(-c2ccc(C(=O)C(OC)c3ccc(N4CCOCC4)cc3)o2)cc(OC)c1OC(=O)c1ccccc1

HCID58432160

未命名化合物

收率 50%

CONDITIONS

反应条件

温度: 0 °C

PROCEDURE

实验过程

4-(Furan-2-yl)-2,6-dimethoxyphenyl benzoate was reacted with N,2-dimethoxy-N-methyl-2-(4-morpholinophenyl)acetamide according to the procedure described for the synthesis of Example 12 except that the reaction was warmed to only 0° C. Purification by chromatography (EtOAc-hexanes) provided 2,6-dimethoxy-4-(5-(2-methoxy-2-(4-morpholinophenyl)acetyl)furan-2-yl)phenyl benzoate as a yellow solid (0.257 g, 50% yield). MS: m/z 558.2 [M+H]+.

WORKUP

后处理

customdescribed for the synthesis of Example 12 except that the reaction
customPurification by chromatography (EtOAc-hexanes)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-13cf5c8728c74cb08f54c85edd9ee93c
来源数据集: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09434707B2
来源说明: uspto-grants-2016_09

反应 SMILES

[C:1]([O:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][C:13]([C:18]2[O:19][CH:20]=[CH:21][CH:22]=2)=[CH:12][C:11]=1[O:23][CH3:24])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CON(C)[C:28](=[O:44])[CH:29]([O:42][CH3:43])[C:30]1[CH:35]=[CH:34][C:33]([N:36]2[CH2:41][CH2:40][O:39][CH2:38][CH2:37]2)=[CH:32][CH:31]=1>>[C:1]([O:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][C:13]([C:18]2[O:19][C:20]([C:28](=[O:44])[CH:29]([O:42][CH3:43])[C:30]3[CH:31]=[CH:32][C:33]([N:36]4[CH2:37][CH2:38][O:39][CH2:40][CH2:41]4)=[CH:34][CH:35]=3)=[CH:21][CH:22]=2)=[CH:12][C:11]=1[O:23][CH3:24])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1