Ammonium Chloride → HCID 10829728, compound

Participants

Reaction Steps

A solution of sodium tert-pentoxide (70 ml of a 1M solution), prepared for immediate use, is added to a suspension of methyl(triphenyl)phosphonium iodide (25 g, 61.8 mmol) in 50 ml of toluene, and the mixture is stirred at room temperature under nitrogen for 20 minutes. The compound obtained in Step 1 (6.70 g, 20.6 mmol) dissolved in 50 ml of toluene is added dropwise and the reaction mixture is refluxed for 3 hours. After cooling, the reaction mixture is hydrolysed with a saturated NH4Cl solution and extracted with ether. The organic phase is washed with a saturated NaCl solution, H2O, dried over MgSO4 and concentrated in vacuo. The title product is purified by flash chromatography over a column (SiO2, toluene/cyclohexane:60/40).

Provenance & Evidence