Potassium Cyanide → HCID 10585357, compound

Participants

Reaction Steps

410 mg of KCN (6.3 mmol) and 340 mg of NH4Cl (6.3 mmol) are added, in succession, to a solution, stirred vigorously and maintained under nitrogen, containing 1.25 g (6.2 mmol) of the compound obtained in Step 4 in 30 ml of MeOH and 15 ml of water. After stirring for 12 hours at 20° C., the solution is diluted in CH2Cl2 and extracted with CH2Cl2. The organic phase is washed with a saturated NaCl solution, dried over MgSO4 and evaporated. The residue is treated with 25 ml of a methanolic solution of ammonia (7N) and stirred in a closed system for 12 hours at 20° C. Evaporation under reduced pressure yields the title compound in pure form.

Provenance & Evidence