HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalate → HCID 22111301, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalate | HCID 71081 | — |
| Reactant | HCID 15485945 | HCID 15485945 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22111301 | HCID 22111301 | 70% |
Reaction Steps
The title compound was prepared in 70% yield in two steps from LAH reduction of methyl 4-[4-[1-[3-methoxy-4-[(1-pyrrolidinyl)methyl]benzyl]indol-2-yl]phenoxy]butyrate (free base of Example 8) in THF at 0° C. for 1 h, followed by oxalate formation as previously described.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06172100B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-5bedda535f8f414f844cf394051fcd84 |
| Source note | uspto-grants-2001_01 |