Morpholine → 3-Amino-3-morpholinoacrylonitrile

HRID 565439Notes

Reaction equation

HRID 565439 reaction equation
[C:1]([CH2:3][C:4](=[NH:8])OCC)#[N:2].[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>C(O)C>[NH2:8][C:4]([N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)=[CH:3][C:1]#[N:2]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 256188Ethyl 2-cyanoethanecarboximidate

Product 1

HCID 27636313-Amino-3-morpholinoacrylonitrile

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In anhydrous ethanol (10 ml) was dissolved ethyl 2-cyanoacetimidate (1.0 g), followed by addition of morpholine (0.78 g). The mixture was stirred at room temperature for 4 hours, and the separated crystals were collected by filtration. This crystal crop was used as it was in the next reaction.

Workup

  1. filtrationthe separated crystals were collected by filtration
  2. customwas in the next reaction

Sources & evidence

ORD record
ord-fd12486b577e4589a54a67f04c396b41
Source dataset
uspto-grants-2001_01
Patent number
US06172102B2

Reaction notes

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