HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Piperazinecarboxaldehyde → (2S)-(-)-1-(4-indolyloxy)-3-(4-(formyl)piperazin-1-yl)-2-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Piperazinecarboxaldehyde | HCID 82191 | — |
| Reactant | (2s)-Glycidyl indol-4-yl ether | HCID 10943254 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (2S)-(-)-1-(4-indolyloxy)-3-(4-(formyl)piperazin-1-yl)-2-propanol | HCID 15895685 | 86% |
Reaction Steps
The title compound was prepared in similar fashion from (S)-(+)-4-(oxiranylmethoxy)-1H-indole and 1-formylpiperazine in 86% yield. mp 106-107°. FDMS m/e=303 (M+ of free base). α[D]589=−1.98 (c=1.0, methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06172073B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-7e53b40d5bb44f148f5b3324ed6c7b28 |
| Source note | uspto-grants-2001_01 |