1-methyl-1H-pyrrole-2-ethylamine → 1-(4-indolyloxy)-3-([2-(1-methyl-1H-pyrrol-2-yl)ethyl]amino)-2-propanol

HRID 565496Notes

Reaction equation

HRID 565496 reaction equation
[O:1]1[CH2:3][CH:2]1[CH2:4][O:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:7]=1[CH:8]=[CH:9][NH:10]2.[CH3:15][N:16]1[CH:20]=[CH:19][CH:18]=[C:17]1[CH2:21][CH2:22][NH2:23]>>[NH:10]1[C:11]2[C:7](=[C:6]([O:5][CH2:4][CH:2]([OH:1])[CH2:3][NH:23][CH2:22][CH2:21][C:17]3[N:16]([CH3:15])[CH:20]=[CH:19][CH:18]=3)[CH:14]=[CH:13][CH:12]=2)[CH:8]=[CH:9]1

Participants

3

Reactant 2

HCID 5650581-methyl-1H-pyrrole-2-ethylamineHCID 6050154-(oxiran-2-ylmethoxy)-1H-indole

Product 1

HCID 212682831-(4-indolyloxy)-3-([2-(1-methyl-1H-pyrrol-2-yl)ethyl]amino)-2-propanolYield 60%

Procedure

The title compound was prepared in similar fashion from 4-(oxiranylmethoxy)-1H-indole and 2-(1-methyl-1H-pyrrol-2-yl)ethylamine in 60% yield. FDMS m/e=313. mp 105-106°.

Sources & evidence

ORD record
ord-403752e3053b4c7792490171f0dfd890
Source dataset
uspto-grants-2001_01
Patent number
US06172073B2

Reaction notes

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