HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 86750002, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | 1,2,3,6-Tetrahydro-4-phenylpyridine | HCID 82553 | — |
| Reactant | (2s)-Glycidyl indol-4-yl ether | HCID 10943254 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86750002 | HCID 86750002 | — |
Reaction Steps
The title compound was prepared according to Example 1 from (S)-(+)-4-(oxiranylmethoxy)-1H-indole and 4-phenyl-1,2,3,6-tetrahydropyridine. The resulting free base was dissolved in ethyl acetate, and precipitated with one equivalent of oxalic acid in ethyl acetate in 60% overall yield as a white foam. FDMS m/e=348 (M+ of free base). α[D]589=−17.09 (c=0.49, methanol)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06172073B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-92ff93a91a1140f797b1274622bd5482 |
| Source note | uspto-grants-2001_01 |