HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → (2S)-(+)-3-[4-(7-chloro-3-indolyl)piperidin-1-yl]-1-(4-indolyloxy)-2-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | (2s)-Glycidyl indol-4-yl ether | HCID 10943254 | — |
| Reactant | 7-chloro-3-(piperidin-4-yl)-1H-indole | HCID 12072036 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (2S)-(+)-3-[4-(7-chloro-3-indolyl)piperidin-1-yl]-1-(4-indolyloxy)-2-propanol | HCID 57102677 | — |
Reaction Steps
The title compound was prepared in a fashion similar to that described in Example 1 using (S)-(+)-4-(oxiranylmethoxy)-1H-indole (0.406 g, 2.13 mmol) and 7-chloro-3-(piperidin-4-yl)-1H-indole (0.500 g, 2.13 mmol) using ethanol as reaction solvent. Yield 0.325 g (35%) as a colorless powder. mp 186-189° C. FDMS m/e=423 (M+ of free base). α[D]589=+8.44 (c=1.09, dimethylsulfoxide).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06172073B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-24f0350170934e7e9426ecf3a901857b |
| Source note | uspto-grants-2001_01 |