HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → (2R)-(-)-3-[4-(6-chloro-3-indolyl)-1,2,3,6-tetrahydropyridin-1-yl]-1-(5-quinolinyloxy)-2-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | (R)-5-(Oxiran-2-ylmethoxy)quinoline | HCID 11735808 | — |
| Reactant | 6-chloro-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole | HCID 21268347 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (2R)-(-)-3-[4-(6-chloro-3-indolyl)-1,2,3,6-tetrahydropyridin-1-yl]-1-(5-quinolinyloxy)-2-propanol | HCID 53815837 | — |
Reaction Steps
The title compound was prepared in a fashion similar to that described in Example 1 using (R)-5-(oxiranylmethoxy)-quinoline (0.495 g, 2.46 mmol) and 6-chloro-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (0.519 g, 2.33 mmol) using ethanol as reaction solvent. Yield 0.840 g (87%) of a tan powder. FDMS m/e=433 (M+ of free base). mp 221-223° C. α[D]589=−9.9 (c=1.00, dimethylsulfoxide).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06172073B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-4a51288adbfe453c9bb7806b940f6599 |
| Source note | uspto-grants-2001_01 |