HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Methoxy-1H-indole → 6-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Methoxy-1H-indole | HCID 76659 | — |
| Reactant | Piperonylamine | HCID 2723901 | — |
| Product | 6-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole | HCID 13019005 | — |
Reaction Steps
The title compound was prepared in a fashion similar to that described in Preparation 30 from 6-methoxyindole (2.0 g, 14 mmol) and 4-piperidone hydrochloride hydrate (4.2 g, 27 mmol). The product was isolated as a yellow solid. Yield 2.8 g (90%). mp 190-193° C. FDMS m/e=228 (M+ of free base).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06172073B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-fcfd0b8744cc4d39a83f457d53d20c23 |
| Source note | uspto-grants-2001_01 |