Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 3-[4-(5-Chloro-3-indolyl)-1,2,3,6-tetrahydropyridin-1-yl]-1-(4-indolyloxy)propane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole | HCID 3050532 | — |
| 반응물 | 4-(3-chloropropoxy)-1H-indole | HCID 11694169 | — |
| 생성물 | 3-[4-(5-Chloro-3-indolyl)-1,2,3,6-tetrahydropyridin-1-yl]-1-(4-indolyloxy)propane | HCID 21268298 | — |
반응 단계
The title compound was prepared in a fashion similar to that described in Example 192 from 5-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (0.50 g, 2.2 mmol), 1-chloro-3-(1H-indole-4-oxy)propane (0.45 g, 2.2 mmol) and potassium carbonate (0.35 g, 2.5 mmol). The product was isolated as a white foam. Yield 220 mg (25%). mp 198-202° C. FDMS m/e=406 (M+ of free base).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06172073B2 |
| 출처 데이터셋 | uspto-grants-2001_01 |
| ORD ID | ord-3e611651bb3f4c12b137fdf815233509 |
| 출처 메모 | uspto-grants-2001_01 |