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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 565547Generated: October 25, 2026

Potassium Carbonate → 3-[4-(6-Trifluoromethyl-3-indolyl)-1,2,3,6-tetrahydropyridin-1-yl]-1-(4-indolyloxy)propane

https://huagongshe.com/reaction/565547

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactant6-trifluoromethyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoleHCID 11242561—
Reactant4-(3-chloropropoxy)-1H-indoleHCID 11694169—
Product3-[4-(6-Trifluoromethyl-3-indolyl)-1,2,3,6-tetrahydropyridin-1-yl]-1-(4-indolyloxy)propaneHCID 21268286—

Reaction Steps

The title compound was prepared in a fashion similar to that described in Example 192 from 6-trifluoromethyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (0.50 g, 1.9 mmol), 1-chloro-3-(1H-indole-4-oxy)propane (0.39 g, 1.9 mmol) and potassium carbonate (0.29 g, 2.1 mmol). The product was isolated as a white foam. Yield 0.53 g (64%). mp 190-195° C. FDMS m/e=440 (M+ of free base).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06172073B2
Source datasetuspto-grants-2001_01
ORD IDord-aa107dfb1fbf498396bb77a2e55cc814
Source noteuspto-grants-2001_01