HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 3-[4-(6-Trifluoromethyl-3-indolyl)-1,2,3,6-tetrahydropyridin-1-yl]-1-(4-indolyloxy)propane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-trifluoromethyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole | HCID 11242561 | — |
| Reactant | 4-(3-chloropropoxy)-1H-indole | HCID 11694169 | — |
| Product | 3-[4-(6-Trifluoromethyl-3-indolyl)-1,2,3,6-tetrahydropyridin-1-yl]-1-(4-indolyloxy)propane | HCID 21268286 | — |
Reaction Steps
The title compound was prepared in a fashion similar to that described in Example 192 from 6-trifluoromethyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (0.50 g, 1.9 mmol), 1-chloro-3-(1H-indole-4-oxy)propane (0.39 g, 1.9 mmol) and potassium carbonate (0.29 g, 2.1 mmol). The product was isolated as a white foam. Yield 0.53 g (64%). mp 190-195° C. FDMS m/e=440 (M+ of free base).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06172073B2 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-aa107dfb1fbf498396bb77a2e55cc814 |
| Source note | uspto-grants-2001_01 |