1,1'-Carbonyldiimidazole → HCID 21268366, compound

Participants

Reaction Steps

A mixture of 1-benzyl-4-(3-methylphenyl)-4-aminomethyl-piperidine (0.52 g, 1.67 mmol) and 1,1′-carbonyldiimidazole (0.41 g, 2.5 mmol) in dichloromethane (2 mL) was stirred at room temp. for 3 days. The resultant solution was concentrated and the residue subjected to column chromatography on silica gel eluting with a 1:1 mixture of chloroform and chloroform saturated with ammonia gas. Collection and concentration of appropriate fractions provide the title compound. FAB MS m/e 336 (M+1)

Provenance & Evidence