Hydrogen Bromide → HCID 22111472, compound

Participants

Reaction Steps

A round bottom flask provided with a condenser was supplied with 6.0 g of 2,3,4,5,6-pentafluoro-4′-methoxybenzophenone, 40 ml of glacial acetic acid, and 30 ml of an aqueous 48% hydrogen bromide solution. The resultant mixture was refluxed overnight and then cooled to a room temperature. The product was extracted from diethyl ether, dried with magnesium sulfate, filtered, and separated by distillation. It was recrystallized from toluene, to afford as white crystals 3.7 g (yield 78.8%) of 2,3,4,5,6-pentafluoro-4′-hydroxybenzophenone (hereinafter referred to as “HPBP”). The melting point of the product was 142° to 143° C. The NMR chemical shift of the crystals is shown in Table 1.

Provenance & Evidence