Water → HCID 22110967, compound

Participants

Reaction Steps

To a solution of N-[2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperidinyl)methyl]benzofuran-5-yl]acetamide (0.56 g) in tetrahydrofuran (8 mL) was added 0.11 g of lithium aluminum hydride in small portions under ice-cooling. The mixture was then refluxed for 30 hours. After this reaction mixture was cooled with ice, 0.42 g Hyflo Super-Cel (tradename) and ethyl acetate were added, further followed by addition of water (0.2 mL). The mixture was stirred vigorously and, then, filtered and the filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography (hexane:ethyl acetate=5:1) to provide 0.35 g of the title compound. Yield 63%.

Provenance & Evidence