Benzhydrol → 4-[3-(Dipenylmethoxy)propyl]piperidine

HRID 565641Notes

Reaction equation

HRID 565641 reaction equation
[CH:1]([OH:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC([N:22]1[CH2:27][CH2:26][CH:25]([CH2:28][CH2:29][CH2:30]O)[CH2:24][CH2:23]1)=O)(C)(C)C>>[C:2]1([CH:1]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[O:14][CH2:30][CH2:29][CH2:28][CH:25]2[CH2:26][CH2:27][NH:22][CH2:23][CH2:24]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7037BenzhydrolHCID 2800739tert-Butyl 4-(3-hydroxypropyl)tetrahydro-1(2h)-pyridinecarboxylate

Product 1

HCID 222380794-[3-(Dipenylmethoxy)propyl]piperidineYield 90%

Procedure

Using benzhydrol and 1-(tert-butoxycarbonyl)-4-piperidinepropanol, the procedure of Reference Example 23 was otherwise repeated to provide the title compound. Yield 90%.

Sources & evidence

ORD record
ord-6bb55c01c0b64dc4bcc195e1fdafdd8b
Source dataset
uspto-grants-2001_01
Patent number
US06172085B2

Reaction notes

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