反应详情

To a solution of 5,5-diphenylvaleronitrile (6.5 g) in methanol (30 mL), 80 mL of water and 10 g of sodium hydroxide were added, and the mixture was refluxed for 72 hours. After the reaction mixture was allowed to cool, it was washed with diethyl ether and adjusted to pH 1 with concentrated hydrochloric acid. This acidic solution was extracted with diethyl ether and the extract was washed with saturated aqueous NaCl, dried over MgSO4, and concentrated. The residue was recrystallized to provide 5.5 g of the title compound.

1. temperaturethe mixture was refluxed for 72 hours
2. temperatureto cool
3. washit was washed with diethyl ether
4. extractionThis acidic solution was extracted with diethyl ether
5. washthe extract was washed with saturated aqueous NaCl
6. dry with materialdried over MgSO4
7. concentrationconcentrated
8. customThe residue was recrystallized