Sodium Hydroxide → HCID 23667828, compound

Participants

Reaction Steps

To a solution of ethyl 1-[(5-amino-2,4,6,7-tetramethyl-2,3-dihydrobenzofuran-2-yl)methyl]-4-piperidinecarboxylate (10 g) in ethanol (40 mL) was added 5.7 mL of 5N-aqueous sodium hydroxide and the mixture was stirred under nitrogen gas at room temperature for 2 hours. The precipitate was collected by filtration and washed with diethyl ether to provide 7.5 g of the title compound. Yield 75%. The filtrate was concentrated under reduced pressure and the solid residue was washed thoroughly with diethyl ether to provide an additional 1.4 g of the title compound. Yield 14%. These products were not further purified but directly submitted to the next reaction.

Provenance & Evidence