Benzhydrylamine → HCID 22110990, compound

Participants

Reaction Steps

To a suspension of sodium 1-[(5-amino-2,4,6,7-tetramethyl-2,3-dihydrobenzofuran-2-yl)methyl]-4-piperidinecarboxylate (0.89 g) in N,N-dimethylformamide (10 mL) was added 0.35 g of triethylamine hydrochloride and the mixture was stirred at room temperature for 5 minutes. To this mixture were added 0.34 g of 1-hydroxybenzotriazole and 0.46 g of 1,1-diphenylmethylamine. Then, under ice-cooling, 0.48 g of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride was added. This mixture was stirred under nitrogen gas at room temperature for 23 hours. This reaction mixture was diluted with water and extracted with 2 portions of ethyl acetate. The pooled organic layer was washed with water and saturated aqueous NaCl, dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was recrystallized from methanol/diisopropyl ether to provide 0.71 g of the title compound. Yield 57%.

Provenance & Evidence