4-((Diphenylmethoxy)methyl)piperidine → Tert-butyl [2-[2-[4-[(diphenylmethoxy)methyl]-1-piperidinyl]ethyl]-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-5-yl]carbamate

HRID 565666Notes

Reaction equation

HRID 565666 reaction equation
Br[CH2:2][CH2:3][C:4]1([CH3:24])[CH2:8][C:7]2[C:9]([CH3:23])=[C:10]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[C:11]([CH3:14])=[C:12]([CH3:13])[C:6]=2[O:5]1.[C:25]1([CH:31]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[O:32][CH2:33][CH:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[C:25]1([CH:31]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[O:32][CH2:33][CH:34]2[CH2:39][CH2:38][N:37]([CH2:2][CH2:3][C:4]3([CH3:24])[CH2:8][C:7]4[C:9]([CH3:23])=[C:10]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[C:11]([CH3:14])=[C:12]([CH3:13])[C:6]=4[O:5]3)[CH2:36][CH2:35]2)[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 27624204-((Diphenylmethoxy)methyl)piperidineHCID 54438432Tert-butyl [2-(2-bromoethyl)-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-5-yl]carbamate

Product 1

HCID 54143297Tert-butyl [2-[2-[4-[(diphenylmethoxy)methyl]-1-piperidinyl]ethyl]-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-5-yl]carbamateYield 82%

Procedure

Using tert-butyl [2-(2-bromoethyl)-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-5-yl]carbamate and 4-[(diphenylmethoxy)methyl]piperidine, the procedure of Reference Example 58 was otherwise repeated to provide the title compound. Yield 82%.

Sources & evidence

ORD record
ord-12bf5ecd74f94b82bd823b4e88729577
Source dataset
uspto-grants-2001_01
Patent number
US06172085B2

Reaction notes

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