4-(2-(Diphenylmethoxy)ethyl]piperidine → Tert-butyl [2-[2-[4-[2-(diphenylmethoxy)ethyl]-1-piperidinyl]ethyl]-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-5-yl]carbamate

HRID 565667Notes

Reaction equation

HRID 565667 reaction equation
Br[CH2:2][CH2:3][C:4]1([CH3:24])[CH2:8][C:7]2[C:9]([CH3:23])=[C:10]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[C:11]([CH3:14])=[C:12]([CH3:13])[C:6]=2[O:5]1.[C:25]1([CH:31]([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[O:32][CH2:33][CH2:34][CH:35]2[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[C:25]1([CH:31]([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[O:32][CH2:33][CH2:34][CH:35]2[CH2:40][CH2:39][N:38]([CH2:2][CH2:3][C:4]3([CH3:24])[CH2:8][C:7]4[C:9]([CH3:23])=[C:10]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[C:11]([CH3:14])=[C:12]([CH3:13])[C:6]=4[O:5]3)[CH2:37][CH2:36]2)[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 107326614-(2-(Diphenylmethoxy)ethyl]piperidineHCID 54438432Tert-butyl [2-(2-bromoethyl)-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-5-yl]carbamate

Product 1

HCID 54384639Tert-butyl [2-[2-[4-[2-(diphenylmethoxy)ethyl]-1-piperidinyl]ethyl]-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-5-yl]carbamateYield 83%

Procedure

Using tert-butyl [2-(2-bromoethyl)-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-5-yl]carbamate and 4-(2-(diphenylmethoxy)ethyl]piperidine, the procedure of Reference Example 58 was otherwise repeated to provide the title compound. Yield 83%.

Sources & evidence

ORD record
ord-425a1739149d423bbeece34b9637e6e0
Source dataset
uspto-grants-2001_01
Patent number
US06172085B2

Reaction notes

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