5,5-diphenylpentanoic Acid → 2-[[4-(5,5-Diphenylvaleryl)-1-piperazinyl]methyl]-2,3-dihydro-2,4,6,7-tetramethyl-5-benzofuranamine

HRID 565697Notes

Reaction equation

HRID 565697 reaction equation
[CH3:1][C:2]1([CH2:15][N:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)[CH2:6][C:5]2[C:7]([CH3:14])=[C:8]([NH2:13])[C:9]([CH3:12])=[C:10]([CH3:11])[C:4]=2[O:3]1.[C:22]1([CH:28]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH2:29][CH2:30][CH2:31][C:32](O)=[O:33])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:35]1([CH:28]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:29][CH2:30][CH2:31][C:32]([N:19]2[CH2:20][CH2:21][N:16]([CH2:15][C:2]3([CH3:1])[CH2:6][C:5]4[C:7]([CH3:14])=[C:8]([NH2:13])[C:9]([CH3:12])=[C:10]([CH3:11])[C:4]=4[O:3]3)[CH2:17][CH2:18]2)=[O:33])[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1

Participants

3

Reactant 2

HCID 109996075,5-diphenylpentanoic AcidHCID 219977792,3-Dihydro-2,4,6,7-tetramethyl-2-[(1-piperazinyl)methyl]-5-benzofuranamine

Product 1

HCID 221109962-[[4-(5,5-Diphenylvaleryl)-1-piperazinyl]methyl]-2,3-dihydro-2,4,6,7-tetramethyl-5-benzofuranamineYield 86%

Procedure

Using 2,3-dihydro-2,4,6,7-tetramethyl-2-[(1-piperazinyl)methyl]-5-benzofuranamine and 5,5-diphenylvaleric acid, the procedure of Example 10 was otherwise repeated to provide the title compound.

Sources & evidence

ORD record
ord-9ef50c398596443b9c3c67d3f2978641
Source dataset
uspto-grants-2001_01
Patent number
US06172085B2

Reaction notes

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