HCID 22111058, compound → HCID 22111033, compound

HRID 565702Notes

Reaction equation

BrC[CH2:3][C:4]1([CH3:17])[CH2:8][C:7]2[C:9]([CH3:16])=[C:10]([NH2:15])[C:11]([CH3:14])=[C:12]([CH3:13])[C:6]=2[O:5]1.[CH2:18]([N:25]([CH2:32][CH2:33][CH:34]([C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[CH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[NH2:15][C:10]1[C:11]([CH3:14])=[C:12]([CH3:13])[C:6]2[O:5][C:4]([CH2:3][N:29]3[CH2:30][CH2:31][CH:26]([N:25]([CH2:18][C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH2:32][CH2:33][CH:34]([C:35]4[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=4)[C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=4)[CH2:27][CH2:28]3)([CH3:17])[CH2:8][C:7]=2[C:9]=1[CH3:16]

Participants

Reactant 2

HCID 22111058HCID 22111058, compound

HCID 22111087HCID 22111087, compound

Product 1

HCID 22111033HCID 22111033, compoundYield 60%

Procedure

Using 2-bromoethyl-2,3-dihydro-2,4,6,7-tetramethyl-5-benzofuranamine and N-benzyl-N-(3,3-diphenylpropyl)-4-piperidinamine, the procedure of Example 1 was otherwise repeated to provide 1-[(5-amino-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-2-yl)methyl]-N-benzyl-N-(3,3-diphenylpropyl)-4-piperidinamine. Yield 60%.

Sources & evidence

ORD record: ord-593da44c7e3e4314b07c21ee2d0e0b1f
Source dataset: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06172085B2

Reaction notes

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