HCID 22111033, compound → HCID 22111010, compound

Participants

Reaction Steps

To a solution of 1-[(5-amino-2,3dihydro-2,4,6,7-tetramethylbenzofuran-2-yl)methyl]-N-benzyl-N-(3,3-diphenylpropyl)-4-piperidinamine (1.5 g) in ethanol (50 mL) was added 0.30 g of 5% palladium on carbon (50% hydrous) and the mixture was stirred in a hydrogen atmosphere at 5 atmospheric pressure and 40° C. for 6 hours. This reaction mixture was filtered and the filtrate was concentrated under reduced pressure to provide 1.2 g of 1-[(5-amino-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-2-yl)methyl]-N-(3,3-diphenylpropyl)-4-piperidinamine. Yield 94%. This product was treated with 4N-HCl solution in ethanol and the resulting trihydrochloride was recrystallized from ethanol/diethyl ether to provide 1.3 g of the title compound. Yield 82%.

Provenance & Evidence