Sulfuric Acid → HCID 20638932, compound

Participants

Reaction Steps

To a solution of (R)-1-[(5-amino-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-2-yl)methyl]-N-(diphenyl-methyl)-4-piperidinamine (3.5 g) in a mixture of methanol (15 mL) and ethyl acetate (5 mL) was added 2N-sulfuric acid (7.5 mL) and the mixture was concentrated under reduced pressure. To the residue was added methanol (15 mL) and the mixture was stood for 18 hours. The solid formed were collected, dried and recrystallized from methanol-water to provide 3.5 g of the title compound. Yield 75%.

Provenance & Evidence