Sulfuric Acid → HCID 69952059, compound

HRID 565710Notes

Reaction equation

[NH2:1][C:2]1[C:3]([CH3:35])=[C:4]([CH3:34])[C:5]2[O:9][C@@:8]([CH2:11][N:12]3[CH2:17][CH2:16][CH:15]([NH:18][CH:19]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH2:14][CH2:13]3)([CH3:10])[CH2:7][C:6]=2[C:32]=1[CH3:33].[S:36](=[O:40])(=[O:39])([OH:38])[OH:37]>>[S:36]([OH:40])([OH:39])(=[O:38])=[O:37].[NH2:1][C:2]1[C:3]([CH3:35])=[C:4]([CH3:34])[C:5]2[O:9][C@@:8]([CH2:11][N:12]3[CH2:17][CH2:16][CH:15]([NH:18][CH:19]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=4)[CH2:14][CH2:13]3)([CH3:10])[CH2:7][C:6]=2[C:32]=1[CH3:33]

Participants

Reactant 2

HCID 1118Sulfuric Acid

HCID 54528448HCID 54528448, compound

Product 1

HCID 69952059HCID 69952059, compoundYield 68%

Procedure

Using (S)-1-[(5-amino-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-2-yl)methyl]-N-(diphenylmethyl)-4-piperidinamine and 2N-sulfuric acid, the procedure of Example 57 was otherwise repeated to provide the title compound. Yield 68%

Sources & evidence

ORD record: ord-07b3354ddcac47049edbe70f09b5d116
Source dataset: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06172085B2

Reaction notes

Loading…