Acetic Acid → HCID 22611712, compound

Participants

Reaction Steps

1.3 ml of acetic acid, 1.3 ml of distilled water and 1.40 g of iron were added to a suspension of 0.90 g of ethyl 1-[4-benzylamino-5-nitropyrimidin-2-yl)-4-piperidinecarboxylate (Reference Example 6) in 50 ml of ethanol and the reaction solution was refluxed for 5 hours. The dark blue solution was filtered to remove the insoluble substance, and concentrated under reduced pressure to obtain the thin yellow oily product. The resulting product was dissolved in dichloromethane and washed with 10% sodium carbonate(50 ml×2). The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 0.57 g of the title compound as a oily product.

Provenance & Evidence