(S)-mandelic acid → HCID 70239495, compound

Participants

Reaction Steps

Methyl N-[(S)-α-methylbenzyl]-(RS)-pipecolate (157 mg) was dissolved in methyl tert-butyl ether (2 ml) at room temperature. To this solution was added a mixture of L-(+)-mandelic acid (86 mg) and methyl tert-butyl ether (2 ml) at room temperature and stirred. The resulting solution was allowed to stand at −20° C. for one day to form a crystal. The crystals were separated by filtration and dried to yield an L-(+)-mandelic acid salt of methyl N-[(S)-α-methylbenzyl]-(S)-pipecolate (79.9 mg) in an optical purity of 73% de and a yield of 23%.

Provenance & Evidence