HCID 70239410, compound → HCID 70239495, compound

Participants

Reaction Steps

Methyl N-[(S)-α-methylbenzyl]-(RS)-pipecolate (159 mg) was dissolved in methyl tert-butyl ether (2 ml) at room temperature. To this solution was added a mixture of (2S)-L-(−)-malic acid (120 mg) and methyl tert-butyl ether (2 ml) at room temperature and stirred. The resultant solution was allowed to stand at −20° C. for one day to form crystals. The crystals were separated by filtration and dried to yield a (2S)-L-(−)-malic acid salt of methyl N-[(S)-α-methylbenzyl]-(S)-pipecolate (70.8 mg) in an optical purity of 41% de and a yield of 29%.

Provenance & Evidence