Cyclopropylamine → HCID 22111631, compound

HRID 565744Notes

Reaction equation

[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][S:14](Cl)(=[O:16])=[O:15].[CH:18]1([NH2:21])[CH2:20][CH2:19]1>>[CH:18]1([NH:21][S:14]([CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][Br:1])(=[O:16])=[O:15])[CH2:20][CH2:19]1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 22111638HCID 22111638, compound

Product 1

HCID 22111631HCID 22111631, compoundYield 96.6%

Procedure

The reaction was carried out in the same manner as in Preparation Example 3 except for using 12-bromododecanesulfonyl chloride (2.92g, 8.4 mmol) in place of 6-bromohexanesulfonyl chloride, and cyclopropylamine (1.08g, 18.5 mmol), to give N-cyclopropyl-12-bromododecanesulfonamide (2.99 g) as colorless crystals.

Workup

customThe reaction was carried out in the same manner as in Preparation Example 3 except

Sources & evidence

ORD record: ord-e41b5495313d4a9583757e8439f629da
Source dataset: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06172228B2

Reaction notes

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